Using ultrasound to measure the flow of eye blood vessel (Central Retinal Vein) to assess hydration status

In adult pre-operative patients undergoing ocular doppler exam and echocardiography, what is the degree of correlation between Central Retinal Venous flow velocity and Left Ventricular End-Diastolic Area Index?

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000982011

Acronym

CREVOL

Enrollment

Registered

2010-11-15

Start date

2010-11-12

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of this study is to test a simple and non-invasive method for estimating intravascular volume status. Estimation of intravascular volume status (hydration status) is of crucial importance in treating patients in various specialties including intensive care. The current methods available are mostly invasive. The non-invasive methods currently in vogue are resource intensive. Hence, there is a need for a simple, consistent and reliable measure for assessment of intravascular volume status. With this view, this study proposes the use of Central Retinal Venous blood flow velocity as an index of intravascular volume status.

Interventions

After obtaining informed consent, the patient's height and weight are recorded. Then the patient is asked to lie supine. ECG dots are placed on the chest to time Echocardiography as per the normal routine. A clear occlusive shield is placed over one eye and an Doppler Ultrasound probe is placed. The Maximum and Minimum flow velocities of the Central Retinal Vein is measured for four cardiac cycles. Then the occlusive shield is removed. This procedure takes approximately 10 minutes.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Adult patients (18 years of age and above), who present for undergoing elective surgery at the QE II Jubilee hospital, Coopers plains, QLD 4108, Australia.

Exclusion criteria

1. Pre existing eye diseases like documented Diabetic and hypertensive complications in the eye (Diabetes Mellitus and Hypertension per se do not exclude the patient). 2. Glaucoma 3. Patients who have sustained Eye injuries 4. Patients presenting for Eye surgery 5. Patients who had previous eye surgeries other than uncomplicated cataract removal and minor eye procedures 6. Any other contra-indication to performing a routine ocular Doppler examination 7. Patients presenting for Emergency surgeries 8. Evidence of Increased Intra-cranial pressure 9. History of Epilepsy 10. Patients with evidence of heart failure 11. Pregnant women 12. Children 13. Patients who refuse consent.

Outcome results