None listed
Conditions
Brief summary
Obesity and asthma are two of the most common conditions affecting Australian children and adolescents. Epidemiological studies have indicated a link exists between obesity and asthma. Obesity is associated with chronic systemic inflammation. Given that asthma is characterised by chronic inflammation of the airways, we hypothesise that obesity is amplifying airway inflammation and impacting adversely on clinical asthma outcomes in children and adolescents.
Interventions
The intervention is a 10week diet-induced weight loss intervention. Participants receive weekly support from an Accredited Practising Dietitian. Face-to-face consults are for 30-60mins in weeks 0, 1,2, 4, 6, 8, and 10 with phone consults for 10mins on alternate weeks. Individual estimated energy requirements are reduced by 2000kj with the aim of weight loss.
Sponsors
A/Prof Lisa Wood
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
8 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
Doctor-diagnosed stable asthma; obesity (BMI z-score equal / greater than 1.64, equating to BMI percentile equal / greater than 95th) Aged 8-17yo
Exclusion criteria
Inflammatory conditions e.g. lupus, cancer Respiratory conditions other than asthma unstable asthma unexplained weight change in previous 3mths cardiovascular / liver / renal disease secondary obesity e.g. medication pregancy drug / alcohol use
Outcome results
None listed