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ALPhA Study: Active Living and Physical Activity as modifiers of postprandial lipaemia and other risk factors of cardiovascular disease.

The effect of continuous and intermittent physical activity on postprandial lipaemia in sedentary men and women

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000953033
Acronym
ALPhA
Enrollment
65
Registered
2010-11-08
Start date
2010-04-07
Completion date
2010-10-04
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Prolonged elevation of fat (triglyceride) concentrations in the blood after a meal increases the risk of developing cardiovascular disease. Moderate to vigorous physical activity is highly effective at lowering the concentration of fat in the blood after a meal. However, studies in rats suggest that frequent sessions of low level activity performed throughout the day may be just as effective as a single session of more intense exercise at lowering the concentration of fat in the blood after a meal. The aim of this study is to compare the effects of one session of 30 minutes of moderate intensity physical activity, to the effects of performing one minute and 40 seconds of low-level physical activity every 30 minutes throughout the day on concentrations of triglyceride, glucose and insulin

Interventions

This is a randomized cross over study, in which, participants will complete the following three, 9 h trials, each separated by at least 7 days: 1) Physical Activity (PA) trial: participants will walk on the treadmill at 60 % of maximal oxygen consumption (VO2max) for 30 min prior to consuming the first meal replacement beverage (MRB) then remained seated for the remainder of the trial; 2) Active Living (AL) trial: participants will walk on the treadmill at the same speed and incline as PA, fo

This is a randomized cross over study, in which, participants will complete the following three, 9 h trials, each separated by at least 7 days: 1) Physical Activity (PA) trial: participants will walk on the treadmill at 60 % of maximal oxygen consumption (VO2max) for 30 min prior to consuming the first meal replacement beverage (MRB) then remained seated for the remainder of the trial; 2) Active Living (AL) trial: participants will walk on the treadmill at the same speed and incline as PA, for 1 min and 40 s every 30 min throughout the trial; and 3) Sedentary (SE) trial: participants will remain seated for the duration. In each trial participants will be fed three MRBs, each providing 0.46 g fat, 0.54 g protein and 1.12 g carbohydrate per kg at 60, 240 and 420 min.

Sponsors

Tracy Perry
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy men and women who do not regularly undertake more than 3 hours of physical activity a week.

Exclusion criteria

Previously diagnosed cardiovascular disease, diabetes, metabolic disease, high cholesterol or high blood pressure Resting blood pressure greater than 140/90 History of venous thrombosis or any abnormality of blood clotting Smoking Medication known to influence lipid or carbohydrate metabolism

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 23, 2026