None listed
Conditions
Brief summary
This prospective, randomized controlled trial will examine the effects of combined aerobic and resistance training on left ventricular remodeling and its relationship to VO2peak in diabetic patients with diastolic dysfunction.
Interventions
Participants in the intervention group will undergo 3 months of combined resistance and aerobic training for three days/week under the supervision of an exercise physiologist and/or post-graduate students enrolled in a clinical exercise science course. The sessions will begin with 5 minutes warm-up followed by 50 minutes of exercises (30 minutes aerobic and 20 minutes power), and 5 minutes of cool-down. Aerobic exercise intensity will be at 70-75% of predetermined peak oxygen consumption (VO2peak). Resistance exercise: 3 different exercises using large muscle groups (chest, back, legs and shoulders), and each exercise will be performed for three sets, 8-12 repetitions. For each session, weights will be adjusted according to the current capacity of the individual. Participants will rest between sets for 120 seconds and between exercises for 120 to 150 seconds. Blood sugar levels (BSL) will be monitored by checking the levels before and after each session.
Sponsors
Study design
Eligibility
Inclusion criteria
Type 2 Diabetic patients with LV diastolic dysfunction as evidenced on echocardiography by a) Deceleration time > 220 msec and/or E’: < 8 cm/s, b) E/E'>10 who are suitable for exercise training intervention
Exclusion criteria
1) Known coronary artery disease or evidence of ischaemia on baseline stress echocardiography. 2) Left ventricular ejection fraction < 45% 3) Significant (moderate or severe) valvular disease 4) Unstable heart failure needing > 2 medication changes in last 3 months 5) Unstable diabetes as evidenced by a) Hypoglycaemic events > 1/week, or b) HbA1c = 9.0%