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Effect of exercise training on left ventricular remodeling in diabetic patients with diastolic dysfunction: a pilot study

Effect of exercise training on left ventricular remodeling in diabetic patients with diastolic dysfunction: a pilot study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000943044
Enrollment
20
Registered
2010-11-04
Start date
2011-04-01
Completion date
2013-07-31
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This prospective, randomized controlled trial will examine the effects of combined aerobic and resistance training on left ventricular remodeling and its relationship to VO2peak in diabetic patients with diastolic dysfunction.

Interventions

Participants in the intervention group will undergo 3 months of combined resistance and aerobic training for three days/week under the supervision of an exercise physiologist and/or post-graduate students enrolled in a clinical exercise science course. The sessions will begin with 5 minutes warm-up followed by 50 minutes of exercises (30 minutes aerobic and 20 minutes power), and 5 minutes of cool-down. Aerobic exercise intensity will be at 70-75% of predetermined peak oxygen consumption (VO2pea

Participants in the intervention group will undergo 3 months of combined resistance and aerobic training for three days/week under the supervision of an exercise physiologist and/or post-graduate students enrolled in a clinical exercise science course. The sessions will begin with 5 minutes warm-up followed by 50 minutes of exercises (30 minutes aerobic and 20 minutes power), and 5 minutes of cool-down. Aerobic exercise intensity will be at 70-75% of predetermined peak oxygen consumption (VO2peak). Resistance exercise: 3 different exercises using large muscle groups (chest, back, legs and shoulders), and each exercise will be performed for three sets, 8-12 repetitions. For each session, weights will be adjusted according to the current capacity of the individual. Participants will rest between sets for 120 seconds and between exercises for 120 to 150 seconds. Blood sugar levels (BSL) will be monitored by checking the levels before and after each session.

Sponsors

Prof David L Hare
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Primary purpose
Prevention

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Type 2 Diabetic patients with LV diastolic dysfunction as evidenced on echocardiography by a) Deceleration time > 220 msec and/or E’: < 8 cm/s, b) E/E'>10 who are suitable for exercise training intervention

Exclusion criteria

1) Known coronary artery disease or evidence of ischaemia on baseline stress echocardiography. 2) Left ventricular ejection fraction < 45% 3) Significant (moderate or severe) valvular disease 4) Unstable heart failure needing > 2 medication changes in last 3 months 5) Unstable diabetes as evidenced by a) Hypoglycaemic events > 1/week, or b) HbA1c = 9.0%

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 8, 2026