Are the combined use of the target-controlled infusion of remifentanil with desflurane during the maintenance phase of general anesthesia lowering the end-tidal concentration of desflurane?

In patients undergoing surgeries pertaining to the muscular skeletal system, are the combined use of the target-controlled infusion of remifentanil with desflurane during the maintenance phase of general anesthesia lowering the end-tidal concentration of desflurane compared with desflurane only group?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000930088

Enrollment

Registered

2010-11-02

Start date

2009-03-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Desflurane is a widely used inhalational anesthetic. It allows for rapid anesthesia induction, rapid recovery of consciousness, and for the recovery of the general motor function. Its shortcomings are that it causes airway irritation, and increases cerebral blood flow (CBF), and in intracranial pressure (ICP). Furthermore, when a high concentration is administered, it stimulates the sympathetic nervous system. Remifentanil is a synthetic opioid that is a specific µ-receptor agonist. When used together with desflurane, remifentanil is considered to be able to make up for the limitations of desflurane and reduce MAC of the anesthetic vapor when maintaining anesthesia. The goals of this study were to determine the effects of a target-controlled concentration of remifentanil combined with desflurane for decreasing end-tidal concentration of desflurane.

Interventions

arm 1: maintenance of anesthesia was done with desflurane and effect target controlled concentration 1ng/ml of intravenous remifentanil during the surgery. arm 2: maintenance of anesthesia was done with desflurane and effect target controlled concentration 2ng/ml of intravenous remifentanil during the surgery Effect target concentration of remifentanil was achieved with TCI (Target controlled infusion, MODULE DPS ORCHESTRA IS3, Fesenius Vial, France).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 49 Years

Healthy volunteers

Inclusion criteria

the patients undergoing surgeries pertaing muscular skeletal system, without the change of body positioning and expected to have a blood loss rate lower than 200ml

Exclusion criteria

body weight lower than 45 kg or greater than 100 kg, history of severe underlying cardiovascular, pulmonary, renal or hepatic disease.

Outcome results