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Comparison of respiratory mechanics according to tidal volume obtained from predicted, current estimated and no body weight prediction method in patients under pressure controlled mechanical ventilation.

Do differences of tidal volume, calculated from predicted, current estimated and no body weight prediction method, change the respiratory mechanics of patients under pressure controlled mechanical ventilation?

Status
Withdrawn
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000912088
Enrollment
20
Registered
2010-10-26
Start date
2010-12-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The Acute Respiratory Distress Syndrome Group (ARDS) determines that we must use 6 ml of kg of predicted body weight in order to offer appropriate measures of tidal volume to patients under mechanical ventilation. But improper methods to predict the body weight may cause damage to patients' lungs. Inadequate tidal volume will reflect in respiratory mechanics alteration.

Interventions

All the calculation will be done for every participant. Each phase correspond to one of the three interventions. Each phase will be performed once over a single day. PHASE 1: calculation of predicted body weight through the formulas:50+0,91(height in centimeters)-152,4 for men and 45,5 +0,91 (height in centimeters)-152,4 for women. The result will be multiplied by 6 ml (this is the ARDS recommendation of protective ventilation) and the final result will be the tidal volume. We'll adjust the pr

All the calculation will be done for every participant. Each phase correspond to one of the three interventions. Each phase will be performed once over a single day. PHASE 1: calculation of predicted body weight through the formulas:50+0,91(height in centimeters)-152,4 for men and 45,5 +0,91 (height in centimeters)-152,4 for women. The result will be multiplied by 6 ml (this is the ARDS recommendation of protective ventilation) and the final result will be the tidal volume. We'll adjust the pressure limit that offers this tidal volume and keep the ventilation for 2 hours. After, the respiratory mechanics will be calculated according to the found tidal volume. PHASE 2: calculation of the current estimated body weight through the formula: [0,98 X calf circumference(cm) + 1,16 X knee height(cm)]+[1,73 X arm circumference (cm)]+0,37 X subscapularis skinfold(mm)]-81,69 for men and [1,27 X calf ircumference(cm)]+[0,87 X knee height(cm)]+0,98 X arm circumference (cm)]+0,4 X subscapularis skinfold(cm)]-62 for women. The result will be multiplied by 6 ml and the final result will be the tidal volume. We'll adjust the pressure limit that offers this tidal volume and keep the ventilation for 2 hours. After, the respiratory mechanics will be calculated according to the found tidal volume. PHASE 3: for no body weight prediction method we'll use the tidal volume observed at the mechanical ventilator initially. After, the respiratory mechanics will be calculated according to this tidal volume. Then the results of respiratory mechanics corresponding to each phase will be compared and defined which prediction body weight method is more appropriate, closer to normal values os respiratory mechanics.

Sponsors

Lilane Maria Alves Silva
Lead SponsorIndividual

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Educational / counselling / training
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

Adult patients, patients under mechanical ventilation, pressure controlled mode, respiratory failure diagnosed, hemodynamically stable patients, sedated patients.

Exclusion criteria

Other ventilatory mode, sepsis diagnosed, presence of respiratory drive.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026