None listed
Conditions
Brief summary
Background: Bariatric surgery is associated with inflammatory and nutritional condition modifications, capable of causing harm to the oral health status. Objective: This study examined the effect of weight loss after Roux-en-Y bypass surgery on energy intake, levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT) and evaluated the oral cavity disease development. Subjects and Methods: interventional and prospective clinical study. Subjects were submitted to Roux-en-Y gastric bypass surgery and evaluated in the pre-surgical period (basal), and at 3, 6 12 and 24 months after surgery. Control Group formed by normal-weight subjects who did not undergo surgery was assessed only once. The energy intake, loss of weight, Body Mass Index (BMI), antioxidant and inflammatory markers concentrations were determined in the basal period in the 6th, 12th and 24th months post surgery. The oral health status was evaluated in the basal period, 12th and 24th month post surgery by incidence of vomiting, teeth hypersensitivity, prevalence of gum bleeding, loosen teeth, salivary flow, buffer capacity. Outcome: Roux-en-Y bypass attenuated proinflammatory and oxidative stress markers, but antioxidant supplementation appears necessary. The high prevalence of vomiting was found to be an underlying risk factor for hypersensitivity, caries and tooth erosion.
Interventions
Subjects were submitted to Y-en-Roux bypass surgery, also known as Capella or Fobi-Capella technique. It promotes gastrojejunal derivation, which is characterized by food restriction and malabsorption. A small gastric pouch is created while the jejunal ring portion is deviated. The remaining stomach is anastomosed in a distance of 75 to 150 cm from the gastric pouch, forming the Y-en-Roux bypass. The average duration of hospitalization was 4.5 days, while the average time of surgery was 3 h and
Subjects were submitted to Y-en-Roux bypass surgery, also known as Capella or Fobi-Capella technique. It promotes gastrojejunal derivation, which is characterized by food restriction and malabsorption. A small gastric pouch is created while the jejunal ring portion is deviated. The remaining stomach is anastomosed in a distance of 75 to 150 cm from the gastric pouch, forming the Y-en-Roux bypass. The average duration of hospitalization was 4.5 days, while the average time of surgery was 3 h and the time of anesthesia was 3.5 h.
Sponsors
Emilia Addison Machado Moreira
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Experimental group: Inclusion criteria were: Body Mass Index: greater than or equal 40 or greater than 35 kg/ m^2 with some form of associated co-morbidity during the period. Control group: Inclusion criteria were: the same age and gender as the experimental group (group submitted a Roux-en-Y bypass surgery), and Body Mass Index between 18.5 and 24.9 kg/ m^2 without associated co-morbidity during the period.
Exclusion criteria
Experimental group: exclusion criteria were psychological disorder; smoking; alcohol or drug dependency, and undergoing treatment with antibiotics and/or anti-inflammatory or immunosuppressant drugs. Control group: exclusion criteria were the presence of diabetes, chronic or acute inflammatory disease, anemia, psychiatric disease, disorders in lipid metabolism, history of trauma, glucose intolerance, cardiovascular disease, ongoing treatment with antibiotics and/or anti-inflammatory or immunosuppressant drugs, alcohol or drug dependency, smoking, and current menstruation.
Outcome results
None listed