None listed
Conditions
Brief summary
The consumption of rye foods has been shown to improve some markers of bowel and metabolic health in humans. However, the effects of rye foods on the activity and numbers of bacteria of the large bowel, which are increasingly being shown to be important mediators of gut health and health more broadly, are poorly understood. It is the primary objective of this study to determine whether the consumption of a rye bread selectively stimulates the growth of the bacteria Bifidobacteria and Lactobacilli in the large bowel of humans.
Interventions
There will be a 4 week lead in period during which all the participants will consume their habitual diets. Faecal samples over a 48 hour period will be collected immediately prior to this period ,to determine habitual profiles, and then at the end of each subsequent fortnight of a 16 week study period.During the first 4 week intervention period half of the participants will be asked to consume a diet containing rye bread ,4 slices per day then crossover after 4 weeks washout period to the comp
There will be a 4 week lead in period during which all the participants will consume their habitual diets. Faecal samples over a 48 hour period will be collected immediately prior to this period ,to determine habitual profiles, and then at the end of each subsequent fortnight of a 16 week study period.During the first 4 week intervention period half of the participants will be asked to consume a diet containing rye bread ,4 slices per day then crossover after 4 weeks washout period to the comparator treatment.
Sponsors
Dr Michael Conlon
Study design
Allocation
Randomised controlled trial
Primary purpose
Prevention
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Men or women aged 18 to 60 years
Exclusion criteria
Presence or history of gastrointestinal disease or other diseases like hepatic, renal or diabetes considered by CSIRO staff to potentially compromise results. Use of antibiotics or probiotics within a month preceding the trial.Use of medicines that may influence the gut tissues or microflora within a month of the trial. Known food allergy, hypersensitivity or intolerance to the study foods.Persons considered by the investigator to be unwilling, unlikely or unable to comprehend or comply with the study protocol. Participation in another research study within 30 days preceding the start of this study.
Outcome results
None listed