None listed
Conditions
Brief summary
The purpose of this project is to study how ventilators (breathing machines) support babies. We are investigating how we use the ventilator with the aim of better matching the babies' natural breathing patterns. The ventilator can vary the pressure it uses to adjust to your baby’s breathing. We set a maximum inflation pressure limit for how high it can go. Previous experience suggests that this having this limit set higher means babies can get a mixture of higher and lower pressures which may irritate some babies. Setting the limit lower means the ventilation pressures are more even. If the ventilator senses that the pressure limit is too low it will sound an alarm.
Interventions
Ventilator pressure limit settings will be compared in random order. The intervention periods (epochs) will last for 20 mins. Each epoch will be preceded by a 10 minute washout period. Infants will be ventilated using assist control volume guarantee mode with the Drager Babylog 8000plus ventilator throughout the study.
The following selection methods will be compared:
[A] The current standard setting in the neonatal intensive care unit (30 cm H2O)
[B] A setting based upon the average delivered
Ventilator pressure limit settings will be compared in random order. The intervention periods (epochs) will last for 20 mins. Each epoch will be preceded by a 10 minute washout period. Infants will be ventilated using assist control volume guarantee mode with the Drager Babylog 8000plus ventilator throughout the study. The following selection methods will be compared: [A] The current standard setting in the neonatal intensive care unit (30 cm H2O) [B] A setting based upon the average delivered PIP for triggered inflations (identified by the researcher) + 5 cm H2O [C] A setting based upon the perceived 'working PIP' (as reported by the staff caring for the baby) + 5 cm H2O
Sponsors
Royal Women's Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
24 Hours to No maximum
Healthy volunteers
No
Inclusion criteria
Stable ventilated infants, ventilated using assist control volume guarantee (AC/VG) for previous 24 hours.
Exclusion criteria
Ventilator changes in previous 4 hours, pH < 7.2, pCO2>80 mmHg, FiO2 > 0.8, acute pneumothoax/pulmonary interstitial emphysema, significant congenital abnormality, severe PVH, receiving muscle relaxants or morphine infusion > 20 ug/kg/hr
Outcome results
None listed