None listed
Conditions
Brief summary
The purpose of this project is to study how ventilators (breathing machines) support babies. We are investigating how we use the ventilator with the aim of better matching the babies' natural breathing patterns. The flow rate affects the speed at which air and oxygen come from the ventilator and affects how quickly your baby’s lungs are filled. Previous experience suggests that higher flow rates can fill the lungs faster but may irritate some babies. Lower flow rates fill your baby’s lungs more slowly and may mean that your baby needs longer to breathe completely in and out. If the ventilator senses that the flow is too low it will sound an alarm
Interventions
Ventilator circuit (bias) flow 4, 6 and 8 L/min will be compared in random order. The intervention periods (epochs) will last for 20 mins. Each epoch will be preceded by a 10 minute washout period. Infants will be ventilated using assist control volume guarantee mode with the Drager Babylog 8000plus ventilator throughout the study
Sponsors
Royal Womens's Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
24 Hours to No maximum
Healthy volunteers
No
Inclusion criteria
Stable ventilated infants, ventilated using assist control volume guarantee (AC/VG) for previous 24 hours.
Exclusion criteria
Ventilator changes in previous 4 hours, pH < 7.2, pCO2>80 mmHg, FiO2 > 0.8, acute pneumothoax/pulmonary interstitial emphysema, significant congenital abnormality, severe PVH, receiving muscle relaxants or morphine infusion > 20 ug/kg/hr
Outcome results
None listed