None listed
Conditions
Brief summary
The purpose of this project is to study how ventilators (breathing machines) support babies. We are investigating how we use the ventilator with the aim of better matching the babies' natural breathing patterns. The backup rate is the speed at which the ventilator works if your baby does not breathe fast enough. Previous experience has suggests that higher backup rates do not give your baby as much chance to breathe for themselves. Slower backup rates give your baby more change to breathe naturally, but when the ventilator takes over it works more slowly.
Interventions
Ventilator back-up rates 30, 40 and 50 /min will be compared in random order. The intervention periods (epochs) will last for 20 mins. Each epoch will be preceded by a 10 minute washout period. Infants will be ventilated using assist control volume guarantee mode with the Drager Babylog 8000plus ventilator throughout the study
Sponsors
Royal Women's Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
24 Hours to No maximum
Healthy volunteers
No
Inclusion criteria
Stable ventilated infants, ventilated using assist control volume guarantee (AC/VG) for previous 24 hours.
Exclusion criteria
Ventilator changes in previous 4 hours, pH < 7.2, pCO2>80 mmHg, FiO2 > 0.8, acute pneumothoax/pulmonary interstitial emphysema, significant congenital abnormality, severe PVH, receiving muscle relaxants or morphine infusion > 20 ug/kg/hr
Outcome results
None listed