Does the perioperative use of Gabapentin reduce analgesia requirements in patients having delayed open reduction and internal fixation of forearm or ankle fractures?

Do patients who are having delayed open reduction and internal fixation of forearm or ankle fractures and who are given gabapentin peri-operatively, when compared with patients not given gabapentin, show lower narcotic analgesic requirements

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000848000

Enrollment

Registered

2010-10-08

Start date

2010-11-05

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Gabapentin is a drug that is officially used to treat chronic pain. This study looks at whether it can help with the more acute pain from having broken bones in the wrist or ankle repaired with screws and plates. This is very painful for a relatively short period and if we find that gabapentin can help with this pain then this could become part of normal treatment.

Interventions

Pre-operative and post-operative treatment with gabapentin for 24 hours. Preoperative dose would normally be 600 mg orally 30 minutes prior to surgery with 300 mg being given orally 8 hourly for 24 hours following completion of surgery. The doses would need to be reduced if a patient with moderate or worse renal failure was recruited.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

Have to have a fracture of the wrist or ankle that is to be treated by internal fixation and be able to understand how to use a PCA device.

Exclusion criteria

Pregnancy, Non-adult patients due to the hospital being non-paediatric, any patient unable to use PCA.

Outcome results