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Associations between periodontal disease and cardiovascular surrogate endpoints in an adult Indigenous population

Associations between periodontal disease and cardiovascular surrogate endpoints following periodontal treatment in an adult Indigenous population with moderate/severe periodontal disease

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000817044
Enrollment
200
Registered
2010-09-30
Start date
2010-06-02
Completion date
2012-01-10
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The relationship between periodontal disease and cardiovascular surrogate endpoints, both of which are high among the Indigenous Australian population, is established. This study seeks to explore the prevalence of cardiovascular surrogate endpoints among this population with periodontal disease, and to determine if implementation of a periodontal intervention leads to improved cardiovascular risk outcomes. There may be benefit in applying this model to other areas of Indigenous health research.

Interventions

The periodontal intervention involves periodontal therapy ie scaling and root planing of a participant's teeth and gums. It occurs at baseline and takes around half an hour to an hour. A registered dental hygienest provides the care.

Sponsors

University of Adelaide
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Treatment
Masking
Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
25 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Indigenous persons aged 25+ years that have lived in their current location for 2+ years, and who plan to live at their current location for the next 2 years, with moderate/severe periodontal disease

Exclusion criteria

Those with rheumatic heart disease history or other cardiac conditions requiring antibiotic prophylaxis for prevention of subacute bacterial endocarditis, or with obvious endodontic lesions or other sources of oral infection.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 28, 2026