Long-term effects of lemonade therapy on hypocitraturic nephrolithiasis and stone recurrence

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000791033

Enrollment

Registered

2010-09-24

Start date

2000-01-01

Completion date

2009-12-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Citrus fruits and juices are a known natural source of dietary citrate. Of all the citrus juices, lemon juice appears to have the highest concentration of citrate. Therefore, lemonade therapy has been proposed as a potential treatment forpatients with hypocitraturia. We prosspectively evaluated the impact of long-term lemonade therapy on urinary metabolic parameters and stone formation in patients with hypocitraturic nephrolithiasis.

Interventions

Lemonade therapy consisted of 120 ml concentrated lemon juice (5.9 gram citric acid) mixed with 2 liters water consumed throughout each day and last for 8 years. The patients were asked to comsume enough fluid to urinate at least 2 L daily.

Eligibility

Sex/Gender

All

Age

45 Years to 55 Years

Healthy volunteers

Inclusion criteria

All patients with a history of hypocitraturic nephrolithiasis ( defined as less than 320 mg citrate in a 24-hour urine collection ) who were aged 45 to 55 years were eligible.

Exclusion criteria

Patients with solitary kidney, renal insufficiency, infectious stones, or active stone disease with pain, hematuria, or obstruction and those taking thiazide-type diuretics were excluded. Pregnancy and ongoing medical treatment for stone disease were also reasons for exclusion.

Outcome results