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Can diagnostic assessment using an ‘Accelerated Pathway’ reduce hospital admissions for chest pain in New Zealand?

A study to compare the effectiveness, when applied to clinical practice of an ‘accelerated’ chest pain diagnostic pathway, against the standard investigative process for adults presenting with possible cardiac chest pain at Christchurch Hospital.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000766011
Enrollment
542
Registered
2010-09-15
Start date
2010-10-11
Completion date
2012-07-04
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The research will provide an innovative and workable change to the medical decision making involved in the investigation, and service delivery for patients presenting acutely to Emergency Departments (ED’s) with possible cardiac chest pain. It is a randomised trial comparing current care with a new ‘fast-track’ pathway. This research will support research knowledge translation by proving the effectiveness in real-time clinical practice, of the findings of recent, promising, cutting edge, New Zealand research. This research suggests that for significant numbers of patients, an ‘accelerated’ chest pain pathway can rule-out Acute Myocardial Infarction (AMI) sooner, enabling earlier progression to the next phase of chest pain investigation(s) and, importantly, allow early discharge from ED, without hospital admission. It is beneficial for the health service, which avoids unnecessary admissions, duplication of staff activities and pressure upon urgent care services.

Interventions

Accelerated Arm - Diagnostic assessment using an ‘accelerated’ chest pain pathway. The pathway incorporates using (i) a risk stratification tool, Thrombolysis in Myocardial Infarction Risk Score (TIMI score), (ii) Electrocardiographs (ECGs) AND (iii) troponin blood test over a 2 hour time period from presentation to the hospital.

Sponsors

Canterbury District Health Board
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Adults > 18 years of age 2. Presenting acutely to Christchurch hospital ED with chest pain (or discomfort) suggestive of AMI for whom, following initial clinical assessment, the attending clinician(s) intends to perform serial Cardiac Troponin (cTns), as part of the current chest pain investigation pathway for possible AMI.

Exclusion criteria

1. ST Segment Elevation Myocardial Infarction (STEMI) present on any ECG. 2. Aged less than 18 years old 3. Proven or suspected non-coronary pathology as the cause of chest pain 4. Patients who will require admission regardless of a negative cTn, due to other medical conditions, need for other investigations or social considerations. 5. Transfers from other hospitals 6. Chest pain episode began over > 12 hours ago and still persisting pain 7. Subjects previously enrolled in this study 8. Patient (or Legal Representative) unable or unwilling to provide informed consent. 9. Anticipated problem with follow-up e.g. resident outside New Zealand 10. Researcher does not feel that recruitment is appropriate (e.g. terminal illness)

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 10, 2026