Reduction of Surgical Site Infection in Cardiac Surgery using a Microbial Sealant-A Controlled Study

In coronary artery bypass patients requiring greater than 2 lengths of saphenous vein for conduit does the application of a cyanoacrylate surgical sealant prior to leg wound incision decrease wound infection rates scored at 1 month when compared to the contralateral leg wound in the same patient.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000743066

Enrollment

100

Registered

2010-09-07

Start date

2008-07-14

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A trial to see if the use of a cyanoacrylate ("Superglue") sealant applied to the skin prior to the surgical incsion can reduce the incidence of post operative wound infections.

Interventions

Application of a cyanoacrylate microbial surgical sealant to the skin surface immediately prior to skin incision for removal of the long saphenous vein for coronary artery bypass surgery. Applied directly from sterile container with sponge applicator. Probable mechanism of action is the fixation of microorganisms within hair follicles and sweat glands, thus reducing quantitatively the contamination of the incision.

Study design

Allocation

Non-randomised trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

40 Years to 90 Years

Healthy volunteers

Inclusion criteria

Isolated Coronary Artery bypass patients requiring greater than 2 lengths of saphenous vein conduit.

Exclusion criteria

Peripheral vascular disease, long saphenous vein abnormality, leg skin lesions or ulcers, prior sensitivity to cyanoacrlate, acetone or formaldehyde containg products, non consent.

Outcome results