None listed
Conditions
Brief summary
The hypothesis is that in healthy humans dietary omega-3 fatty acids and aspirin enhance the formation of the potent antiinflammatory metabolites resolvins and protectins. Specifically, we aim to determine blood resolvin and protectin levels in a randomised controlled trial of aspirin or placebo in healthy men and women taking omega-3 fatty acids.
Interventions
20 healthy men and women will be recruited from the general population by newspaper advertisements. They will be matched for age and gender. They will be asked to take 4 x 1g fish oil capsules daily (Omega Daily, Blackmores Ltd, Australia) supplying 2.4g/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), for 7 days. On the sixth day they will be randomly allocated to take either 3 x 100mg tablets per day of aspirin (Bayer, Australia) or the same number of placebo (microcellulose) t
20 healthy men and women will be recruited from the general population by newspaper advertisements. They will be matched for age and gender. They will be asked to take 4 x 1g fish oil capsules daily (Omega Daily, Blackmores Ltd, Australia) supplying 2.4g/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), for 7 days. On the sixth day they will be randomly allocated to take either 3 x 100mg tablets per day of aspirin (Bayer, Australia) or the same number of placebo (microcellulose) tablets. Volunteers will be asked to take aspirin or placebo tablets on both the sixth and seventh days, in addition to the fish oil. Fish oil capsules and aspirin or placebo tablets will be taken orally. Blood samples will be collected at baseline (day 0), and at days 5 and 7.
Sponsors
Professor Trevor Mori
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Men aged 20-70 years, and post-menopausal women aged less than 70 years will be recruited from the general population by newspaper advertisements. Volunteers will be included if they do not meet any of the criteria for the metabolic syndrome as defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP: ATPIII).
Exclusion criteria
Smokers, history of cardiovascular or peripheral vascular disease, diabetes, renal disease, liver disease or taking anti-hypertensive agents, lipid lowering drugs, hormone replacement therapy (women only), > 2 standard alcoholic drinks for women and >3 standard alcoholic drinks for men per day, aspirin or non-steroidal anti-inflammatory drugs, omega-3 fatty acids or >2 fish meals per week.
Outcome results
None listed