Fish oil supplementation in pregnancy to reduce allergies in early childhood

Conditions

None listed

Brief summary

DHA is an omega-3 fat found in fish and fish oils and is thought to effect an infant's developing immune system. While in the womb, the baby is supplied with DHA from the mothers circulation. This study will help determine whether increasing the amount of DHA in the diet of pregnant women reduces allergies in their children.

Karen P Best, Thomas Sullivan, Debra J. Palmer, Michael Gold, James A. Martin et al. (7 authors)

World Allergy Organization Journal2018-01-0143 citations

10.1186/s40413-018-0190-7

Higher cord blood 25-hydroxyvitamin D concentrations reduce the risk of early childhood eczema: in children with a family history of allergic disease.

Palmer DJ, Sullivan TR, Skeaff CM, Smithers LG, Makrides M, DOMInO Allergy Follow-up Team.

2015-10-0619 citations

10.1186/s40413-015-0077-9

Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial.

Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M.

2012-01-30141 citations

10.1136/bmj.e184

Interventions

3 x 500mg high-DHA rich tuna oil capsules per day taken from 18-21 weeks gestation until birth

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Yes

Inclusion criteria

Child to have a family history of medically diagnosed allergic disease (eczema, asthma, allergic rhinitis): singleton pregnancy less than 18-21 weeks gestation with no known fetal abnormality: mothers not to have had documented history of alcohol or drug abuse: no participation in other clinical trials with fatty acid intervention.

Exclusion criteria

Maternal bleeding disorders where DHA tuna oil is contraindicated

Outcome results