None listed
Conditions
Brief summary
The number of people with asthma has been steadily increasing for many years in most countries of the world including New Zealand, but researchers are not sure why. Some studies have suggested that one reason could be the increasing use of paracetamol. We are aiming to find out if giving paracetamol to people with mild asthma has any effect on their asthma.
Interventions
Subjects randomised to the treatment group will take paracetamol 1g (2 x 500mg tablets) four times per day for 14 days.
Sponsors
Medical Research Institute of New Zealand
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. A doctor’s diagnosis of asthma plus wheeze in the previous 12 months and asthma inhaler use in the previous 12 months 2.18 – 65 years old
Exclusion criteria
1.Patients currently taking a long acting beta agonist (LABA), tiotropium or theophylline. 2.An exacerbation of asthma within the previous 6 weeks requiring prednisone, or nebulised bronchodilator. 3.Current or past cigarette smoking > 10 pack years. 4.History of allergy, sensitivity, potential significant drug interaction or other contra-indication to paracetamol 5.History of liver disease 6.Patients with a current history of regular use of paracetamol, who are unwilling or unable to discontinue use of this medication during the trial period. 7.Previous suicide attempt or current depression score of > 13 on the Hamilton Depression Rating Score (HDRS). 8.Body Mass Index (BMI) < 16.0 kg/m2. 9.Pregnant or breast-feeding women and women of child-bearing age not using adequate contraception. 10.Unable to perform or master techniques of pulmonary function testing. 11.Any other safety concern at the investigator’s discretion.
Outcome results
None listed