Comparing accelerated vs. classic vaccination protocols regarding the efficacy of hepatitis B vaccination in prisoners

Comparison of efficacy of vaccination against hepatitis B infection (anti-hepatitis B surface-antigen (HBS) antibody titers) among prisoners in Iran after administering either accelerated or classic vaccination schedules

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000726055

Enrollment

180

Registered

2010-08-31

Start date

2006-06-20

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

prisoners are among high risk groups for hepatitis B infection considering their high risk behaviors including injecting drug use or sexual behaviors. however classic 6 months vaccination might not be able to provide immunity rapidly enough and accelerated vaccination regimens can be of value in this situation.

Interventions

intramuscular administration of 20 mcg recombinant hepatitis B vaccine followed by the same 20 mcg doses at 1, 4 and 8 weeks after first vaccine dose (Accelerated Vaccination protocol)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

Male

Age

20 Years to 54 Years

Healthy volunteers

Yes

Inclusion criteria

Male prisoners in Shiraz correctional and jail facilities

Exclusion criteria

1.prior history of viral hepatitis B 2.prior history of hepatitis B vaccination 3.those tested positive for HBS antigen or anti-hepatitis B core (HBC) antibody at baseline 4.those with anti HBS antibody of 10 IU/L or more at baseline

Outcome results