None listed
Conditions
Brief summary
Vascular access malfunction, usually presenting with an inadequate access flow (Qa), is the leading cause of morbidity and hospitalization in hemodialysis (HD) patients. A shorter length polymorphism with Guanine Thymine repeat number [(GT)n] >30 in the heme oxygenase-1 (HO-1) gene was associated with better prognosis of arteriovenous fistula (AVF) in hemodialysis (HD) patients. Many methods of thermal therapy have been tried for improving Qa but with limited effects. This randomized trial is designed to evaluate (1) the effect of far infrared therapy (FIR) on access flow and patency of the native arteriovenous fistula (AVF) and (2) the interaction between HO-1 length polymorphism and FIR therapy on access flow (Qa) and patency of arteriovenous fistula (AVF) in HD patients.
Interventions
1. HD patients who are randomized into the treatment group will receive 40 minutes of far infrared therapy (FIR therapy) during hemodialysis three times per week for a year.
2. A Wide Spectrum (WS) TY101 FIR emitter (WS Far Infrared Medical Technology Co., Ltd., Taipei, Taiwan) will be used for FIR therapy. Its generated wavelengths range between 3 and 25 microm (a peak between 5 and 6 microm). The top radiator will be set at a height of 25 cm above the surface of the AV fistula with the treat
1. HD patients who are randomized into the treatment group will receive 40 minutes of far infrared therapy (FIR therapy) during hemodialysis three times per week for a year. 2. A Wide Spectrum (WS) TY101 FIR emitter (WS Far Infrared Medical Technology Co., Ltd., Taipei, Taiwan) will be used for FIR therapy. Its generated wavelengths range between 3 and 25 microm (a peak between 5 and 6 microm). The top radiator will be set at a height of 25 cm above the surface of the AV fistula with the treatment time set at 40 minutes during HD thrice a week for a year.
Sponsors
Taipei Veterans General Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
(1) receiving 4 hours of maintenance HD therapy three times weekly for at least 6 months at Taipei veterans general hospital, (2) using a native AV fistula as the present vascular access for more than 6 months, without interventions within the last 3 months, and (3) creation of AV fistula by similar surgical skills with end-to-side anastomosis at upper extremity.
Exclusion criteria
(1) AV graft (2) Life expectancy less than 12 months (3) Central vein stenosis (4) Factors affecting function of AV fistula, such as severe infection, severe aneurysmal dilatation leading to heart failure, etc.
Outcome results
None listed