Flucloxacillin in Cellulitis: A randomised controlled trial comparing continuous infusion to bolus dosing for uncomplicated cellulitis.

In an adult population with uncomplicated cellulitis presenting to an Emergency Department is flucloxacillin delivered by infusion comparable to bolus dosing for nursing workload and patient discharge at 24 hours?

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000682044

Acronym

FliC

Enrollment

200

Registered

2010-08-18

Start date

2010-10-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this study is to test the hypothesis that by managing Emergency Department patients with uncomplicated cellulitis in a short stay unit with a continuous 24 hour infusion of 8g of intravenous flucloxacillin as opposed to the current standard treatment of four 2g intravenous blouses administered every six hours for 24 hours, significant nursing time and resources would be saved with there being no decrease in the clinical or microbiological cure rate of the cellulitis.

Interventions

Efficacy of 8g Flucloxacillin administered continuously via infusion over 24 hours

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

Patients with cellulitis felt to be clinically suitable for management in an Emergency Department Short Stay Unit.

Exclusion criteria

Abbreviated Mortality in Emergency Department Sepsis Score >4 Physician intends to treat with other than Flucloxacillin 2G Intravenously four times daily Patient has any of the following comorbidities: *Diabetes Mellitus *Chronic Systemic Steroid Use *Immunosuppression Patient will not be contactable by telephone for next 31 days

Outcome results