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Changes in oral sensitivity to oleic acid following dietary modification.

Changes in oral sensitivity (taste thresholds) to oleic acid in lean and overweight/obese humans following consumption of a high-fat (>44%) and low-fat (<20%) diet.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000673044
Enrollment
30
Registered
2010-08-17
Start date
2009-08-10
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Previous studies from our laboratories, have reported variation in taste sensitivity to fatty acids (fats) in humans, and that these variations may be asociated with fat intake and the perception of fat in food, that is, the ability to detect fats in food. Based on this evidence, we were interested in looking at environmental influences (i.e., the intake of a high- or low-fat diet, and how it may influence taste sensitivity to fats, given that habituation of the taste system in response to exposure or deprivation of certain nutrients (sodium, monosodium glutamate), has been previously established. Determinants of fatty acid taste sensitivity are of particular interest, given that sensitivity appears to be associated with specific dietary behaviours (i.e., fat intake) which may be associated with obesity. We hypothesized that the taste system would habituate to environmental conditions, and that consumption of a high- or low fat diet would shift sensitivity, i.e., consumption of a high fat diet would decrease taste sensitivity to fatty acids, meaning that greater concentrations would be required for detection, and conversely, a low-fat diet would increase taste sensitivity

Interventions

Consumption of a high-fat (>45%) and low-fat (<20%) diet both over a 4 week period, with a compulsory 2 week wash-out period in between. Specific high-fat foods, including butter, baked goods, dressing, cheese, chocolate and full-fat diary were delivered to all subjects during the high-fat intervention. Fat intakes (in grams per day) were calculated from Energy Requirements based on age, height, weight, gender and Physical Activity Level (PAL) to constitute 45% total energy intake. For the low-f

Consumption of a high-fat (>45%) and low-fat (<20%) diet both over a 4 week period, with a compulsory 2 week wash-out period in between. Specific high-fat foods, including butter, baked goods, dressing, cheese, chocolate and full-fat diary were delivered to all subjects during the high-fat intervention. Fat intakes (in grams per day) were calculated from Energy Requirements based on age, height, weight, gender and Physical Activity Level (PAL) to constitute 45% total energy intake. For the low-fat diet, subjects were advised by a Nutritionist which foods they were not allowed to consumed including all discretionary fats (oils, lard, butter), full-fat dairy, baked goods, high-fat meats (duck, salami) and what foods they should eat when dining out, i.e., tomato based pasta dishes, or lean meats (chicken / fish). To ensure compliance, weekly diet records were collected from all subjects, whom were informed over how to correctly fill in a diet record by a Nutritionist. Foods were delivered to subjects on a weekly basis, and this is when diet records were also collected.

Sponsors

Food Futures Flagship scholarship
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

Non-smoker, unrestrained eater (as defined by use of the 3 factor eating questionnaire), healthy (free of ill health complications), not on a specific dietary regime (vegan, low-fat, diabetic ect)

Exclusion criteria

Smokers, restrained eaters, individuals with known health complications, i.e., heart diease or diabetes.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026