None listed
Conditions
Brief summary
Chronic obstructive pulmonary disease (COPD) and asthma are the most common respiratory diseases in the community. People with these diseases differ in the way the disease manifests itself and some people have features of both diseases. We know that the best medications for asthma and COPD are different but we do not know if best treatment differs between the different types of asthma, COPD and the overlap of the two conditions. This study will answer this question by identifying people in the community with respiratory disease, assessing how the disease manifests in individuals and the effectiveness of three different standard inhaled medications. We will then group individuals into different clusters (types or patterns of disease manifestation) and determine which clusters respond to which different medication. This information will guide doctors who are treating these diseases.
Interventions
1. Ipratropium 80 mcg inhaled single dose
2.Salbutamol 400 mcg inhaled single dose
3. Budesonide 400 mcg inhaled twice daily for 12 weeks
All participants will receive all interventions in the sequence 1, 2, 3. Interventions 1 and 2 to be administered 1-4 weeks apart. Intervention 3 to be administered over the 12 weeks immediately following intervention 2.
Sponsors
Medical Reseach Institute of New Zealand
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
selected at random from the electoral register wheeze and shortness of breath in the last 12 months
Exclusion criteria
Unable or unwilling to withhold medication prior to study visits. Hypersensitivity to study drug.
Outcome results
None listed