Measurement and evaluation of thiamine concentrations in the blood of Australians who have a history of Diagnostic and Statistical Manual Fourth Edition(DSM IV) alcohol dependence or abuse, after 20 years of supplementing flour with thiamine.

Among Australians who have Diagnostic and Statistical Manual Fourth Edition(DSM IV) alcohol dependence or alcohol abuse, has thiamine supplementation of flour resulted in higher median serum thiamine concentrations than the normal population median reference range thus achieving the planned outcome of reducing the risk of Wernicke-Korsakoff syndrome in Australians.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000661077

Enrollment

180

Registered

2010-08-13

Start date

2010-08-09

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aim of the study is to determine the concentrations of thiamine in blood taken from a sample of Australians who have had alcohol related motor vehicle offences. These measurements will allow an estimation of the prevalence of thiamine deficiency in this sample. Given flour has been supplemented with thiamine in Australia for twenty years a secondary aim is to evaluate whether this public health intervention has prevented thiamine deficiency in the main target group (chronic alcohol misusing persons).

Interventions

A sample of blood taken from each participant ,who presents over a two month period, at a driver assessment clinic will be tested using isocratic high performance liquid chromatography with Chromsystems reagents and protocol to measure the serum thiamine diphosphate

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

Selection Criteria 1.Require assessment for DSM IV Alcohol Dependence by the Driver Assessment Clinic of Drug and Alcohol Services South Australia as a result of multiple driving under the influence of alcohol convictions 2.Able to provide a valid consent to participate in the study

Exclusion criteria

1.Those who have had the surgical procedures: gastrectomy, gastrojejunostomy, partial or total colectomy, gastric bypasses surgery, vertical banded gastroplastyor obesity therapy with an intragastric balloon. 2.Patients who have had recurrent vomiting or chronic diarrhoea resulting from anorexia nervosa, pancreatitis and hyperemnesis gravidarum. 3.Those who have had the following cancer and related conditions: gastric or colon carcinoma, non Hodgkin’s lymphoma, myelomonocitic leukaemia, large B cell lymphoma, myeloid leukaemia, allogenic bone marrow transplantation, acquired immune deficiency syndrome. 4.Those who have renal disease requiring dialysis. 5.Magnesium depletion can result from chronic diuretic therapy, intestinal tract resection and Crohn’s disease. Patients with these conditions would be excluded from this aspect of the study

Outcome results