None listed
Conditions
Brief summary
Weight gain has been associated with increased inflammation and n-3 long chain polyunsaturated fatty acids (fish oil) supplementation have been shown to possess anti-inflammatory properties. This study is investigating whether presupplementation with fish oil, then followed by supplementation with fish oil while following a weight loss program, may assist weight loss and reduce inflammatory biomarkers
Interventions
Participants will consume, by mouth, 6 x 1 g/day fish oil capsules composed of 270mg docosahexaenoic acid (DHA) and 70mg eicosapentaenoic acid (EPA)/capsule for four weeks while following a normal, healthy diet, ie. their normal diet without fast foods/take away foods. Participants will then consume a very low Kilojoule (kJ) diet (VLCD) of 3,000 kJ/day using meal replacements for four weeks while continuing to consume 6 x 1g/day fish oil capsules, also for four weeks. The meal replacements wil
Participants will consume, by mouth, 6 x 1 g/day fish oil capsules composed of 270mg docosahexaenoic acid (DHA) and 70mg eicosapentaenoic acid (EPA)/capsule for four weeks while following a normal, healthy diet, ie. their normal diet without fast foods/take away foods. Participants will then consume a very low Kilojoule (kJ) diet (VLCD) of 3,000 kJ/day using meal replacements for four weeks while continuing to consume 6 x 1g/day fish oil capsules, also for four weeks. The meal replacements will be supplied to participants as part of the study. Participants receive 1 x 20 minutes per week individual education sessions on dietary modification and behaviour change for the four weeks of weight loss.
Sponsors
The University of Newcastle
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Body Mass Index (BMI) between 30 and 40 Can consume fish Can swallow capsules
Exclusion criteria
BMI > 40; Diabetic; Already consuming fish oil caplsules or more than 2 oily fish meals/week; Has an inflammatory condition
Outcome results
None listed