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A Randomized Clinical Trial of Cognitive Activity for the Treatment of Older Adults with Mild Alzheimer's Disease

A Randomized Clinical Trial of Cognitive Activity for the Treatment of Older Adults with Mild Alzheimer's Disease

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000653066
Acronym
PACE-AD
Enrollment
120
Registered
2010-08-11
Start date
2010-01-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this study is to investigate whether a cognitive activity program, specifically designed for people with mild AD and their companions can reduce or slow further cognitive decline and improve quality of life for people with AD. It will also investigate the benefits of this type of program to the companion.

Interventions

Participants with mild Alzheimer's disease (AD) and their companion are randomized to participate in a 12-week program of cognitive activity/stimulation. The sessions focus on different aspects of cognition, learning how these domains are altered in AD and incorporating pencil and paper tasks to demonstrate ways to enhance these areas of thinking. Seven weeks of the program (1x 90-minute session per week) are completed in a group setting with a facilitator. The additional sessions are comple

Participants with mild Alzheimer's disease (AD) and their companion are randomized to participate in a 12-week program of cognitive activity/stimulation. The sessions focus on different aspects of cognition, learning how these domains are altered in AD and incorporating pencil and paper tasks to demonstrate ways to enhance these areas of thinking. Seven weeks of the program (1x 90-minute session per week) are completed in a group setting with a facilitator. The additional sessions are completed at home, with participants provided with materials to complete the set material. Telephone contact is made during the week to address any concerns/questions participants may have. Dyads (participants with AD and their companion) randomized to Arm 1 will attend the sessions together.

Sponsors

Bell Research Fellowship for Health and Ageing
Lead SponsorCharities/Societies/Foundations

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No

Inclusion criteria

Diagnosis of AD (probable or possible) according to the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) Alzheimer's criteria; MMSE score ranging from 18-26; Fluent in written and spoken English; Able and willing to travel to Mercy Hospital, Mt. Lawley; Available carer/companion who is willing to participate.

Exclusion criteria

Severe hearing and/or visual impairment; A diagnosis of a current acute psychiatric disorder; Unstable of life threatening medical condition; Current history of hazardous alcohol consumption; Stroke associated with permanent disability; Unable to commit for the entire six month period.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 29, 2026