None listed
Conditions
Brief summary
Intra-peritoneal instillation of local anaesthetics in laparoscopic procedures reduces post-operative pain, analgesic requirements, the stress response and lengthens the period to first post-operative analgesic requirement. Another alternative approach to accelerate outcomes after operation is intravenous lidocaine. We hypothesized that intravenous lidocaine infusion and intraperitoneal lidocaine instillation reduce the pain after laparoscopic surgery. Therefore we investigated a comparative study on multimodal lidocaine pre emptive analgesia in laparoscopic appendectomy patients.
Interventions
arm1:intravenous (IV) lidocaine infusion:
IV lidocaine administration was performed 2 minute before orotracheal intubation.
Patients in arm1 received an IV bolus injection of lidocaine (1.5 mg/kg) followed by a continuous IV infusion at 2 mg/kg/hr during the operation (60 minutes).
arm2.intraperitoneal lidocaine instillation:
Intraperitoneal instillation of lidocaine (total instillation dose 3.5 mg/kg) were administered immediately after the creation of the pneumoperitoneum and 10 min before th
arm1:intravenous (IV) lidocaine infusion: IV lidocaine administration was performed 2 minute before orotracheal intubation. Patients in arm1 received an IV bolus injection of lidocaine (1.5 mg/kg) followed by a continuous IV infusion at 2 mg/kg/hr during the operation (60 minutes). arm2.intraperitoneal lidocaine instillation: Intraperitoneal instillation of lidocaine (total instillation dose 3.5 mg/kg) were administered immediately after the creation of the pneumoperitoneum and 10 min before the beginning of surgery.
Sponsors
Chung-Ang University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
patients undergoin laparoscopic appendectomy
Exclusion criteria
body weight lower than 45 kg or greater than 100 kg, history of severe underlying cardiovascular, pulmonary, renal or hepatic disease, or allergy to local anaesthetics
Outcome results
None listed