None listed
Conditions
Brief summary
Subgroup analyses will include the effect of vitamin A supplementation in LBW and non LBW infants, male and female infants, immunised and unimmunised infants, infants of families in the poorest and richest quintiles, and by vitamin A intake of mothers. For all deaths verbal autopsy interviews will be conducted.
Interventions
Vitamin A supplementation, 50,000 International Units given orally as a single dose to neonates on the day of birth or in the next 2 days following birth. The active ingredients in the vitamin A capsules will be retinol palmitate (50,000 IU) and minute amounts of vitamin E in soybean oil.
Sponsors
World Health Organization
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
2 Hours to 2 Days
Healthy volunteers
Yes
Inclusion criteria
1.) All births in the study area that are between two hours and two days of age, whose caretakers confirm of intention to remain in the study areas for a minimum of six months thereafter, will be eligible for inclusion in this study. 2.) Both singleton and multiple births are eligible for inclusion in this study and each infant will be provided with their own unique study identification number. 3.) Infants will be included even if they were not identified during pregnancy surveillance.
Exclusion criteria
1.) Unable to feed if offered feeds as reported by the mother 2.) Mother does not intend to stay in the study area for at least 6 months
Outcome results
None listed