The Effect of Combined Ephedrine and Lidocaine Pretreatment on pain and hemodynamic changes due to propofol injection

The effect of combined Ephedrine and Lidocaine pretreatment on pain due to propofol injection in patients undergoing elective surgery under general anaesthesia

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000610033

Enrollment

165

Registered

2010-07-28

Start date

2010-01-08

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Objectives: Injection pain and hypotension are two main adverse effects of propofol which distresses patient. The aim of this prospective double blind study was to compare the effect of ephedrine -lidocaine combination with lidocaine and ephedrine on injection pain and hemodynamic changes due to propofol induction. Methods: 165adult patients, aged 20 to 60 yr, Patients were randomly allocated to one of 5 groups (33 patients per group): lidocaine 0.5 mg/kg(L) ,ephedrine 30microgram/kg (E30), ephedrine 70microgram/kg(E70), lidocaine0.5mg/kg -ephedrine30 microgram/kg(LE) or 2ml saline (S) intravenously.After one minute propofol 2 mg/kg into a dorsal hand vein was injected. Face pain scale and verbal rating scale, arterial blood pressure and heart rate were recorded before induction, just before intubation, and one minute after intubation.

Interventions

Patients were randomly allocated to one of 5 groups (33 patients per group): lidocaine 0.5 mg/kg(L) ,ephedrine 30micrograms/kg (E30)ephedrine 70micrograms/kg(E70),lidocaine0.5mg/kg -ephedrine30 micrograms/kg(LE) or 2ml saline (S)intravenously.participants in each group receive a single dose of the intervention treatment only.After one minute propofol 2 mg/kg into a dorsal hand vein was injected.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

patients with American Society of Anesthesiologists(ASA) physical status I and II, undergoing elective surgery performed under general anesthesia

Exclusion criteria

patients with difficulty in communication, those with a history of adverse response to propofol, lidocaine, or ephedrine, and those with allergic, neurologic or cardiovascular disease and patients, who had received an analgesic medication within 24 hr before surgery

Outcome results