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Moving forward in anorexia nervosa treatment.

A randomised controlled trial of the Loughborough Eating disorders Activity therapy versus general cognitive behavior therapy efficacy in reducing pathological exercise behaviours and cognitions.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610000585022
Acronym
LEAP
Enrollment
78
Registered
2010-07-21
Start date
2010-08-19
Completion date
2015-01-30
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose is to investigate an enhanced psychotherapy for anorexia nervosa. Anorexia nervosa is a serious psychological illness that is associated with much distress and many difficulties for people living with the illness. Many people do not get better with current therapies. Dr Meyer and her colleagues in Loughborough (England) have developed an enhanced form of cognitive behaviour therapy (CBT), which is a psychotherapy or talking therapy for anorexia nervosa. CBT in anorexia nervosa treatment focuses on how people think about eating, weight and shape and what they do about them (e.g. diet to lose weight). The therapy we are testing in this study has been enhanced by focussing more on some features of anorexia nervosa that have been found to be prevent people getting better from anorexia nervosa.

Interventions

The intervention tested is an extended manualised cognitive behaviour therapy.The overarching aim is the promotion of ‘healthy’ (i.e., non-excessive/non-eating disorder related) attitudes, beliefs, and behaviours toward both structured exercise and physical activity in general. It is important to emphasise that the aim of the treatment program is not to make patients stop exercising, but rather to educate them about what constitutes ‘healthy/non-excessive’ exercise and equip them with the knowle

The intervention tested is an extended manualised cognitive behaviour therapy.The overarching aim is the promotion of ‘healthy’ (i.e., non-excessive/non-eating disorder related) attitudes, beliefs, and behaviours toward both structured exercise and physical activity in general. It is important to emphasise that the aim of the treatment program is not to make patients stop exercising, but rather to educate them about what constitutes ‘healthy/non-excessive’ exercise and equip them with the knowledge and skills that will enable them to regain control of their exercise behaviour in order to participate in age, goal and health-status appropriate exercise. The program is designed around four core themes of education, guided discovery, cognitive skills, and relapse prevention. Specifically the following are addressed: Education about the cognitive view on the maintenance of excessive exercise Promotion of insight into the factors affecting (maintaining) the patient’s attitudes, beliefs and behaviours toward exercise Education about what constitutes ‘healthy’ exercise Introduction to the cognitive skills and strategies necessary to challenge maladaptive attitudes, beliefs and behaviours toward exercise Introduction to alternative (adaptive) emotion coping strategies Education about relapse prevention We expect reduced driven exercise behaviour and cognitions. The intervention will be administered during day time hours by a trained therapist. The therapy will comprise 8 weekly one hour sessions and is followed by 6-8 months of weekly cognitive behaviour therapy and then 6 months follow-up after that. The cognitive behaviour therapy admistered in the next 6-8 months (or 8-10 months in the control therapy group) is that developed by Pike et al. (Pike KM, Walsh BT, Vitousek K, et al. Cognitive behavior therapy in the post-hospitalization treatment of anorexia nervosa. Am J Psychiatry,2003; 160, 2046-2049.) All therapy is administered on an individual basis.

Sponsors

University of Western Sydney
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Age >18 years with primary diagnosis of anorexia nervosa according to American Psychiatric Association Diagnostic and Statistical Manual version IV (DSM-IV) of either the restrictive or binge-purge type. Engaging in some form of exercise behaviour over the previous week. Therefore, they will each score >/=1 on item 2 on the Exercise Participation Screening Questionnaire.

Exclusion criteria

Diagnosis of psychosis or bipolar disorder A high level of suicide risk and/or medical compromise precluding outpatient care and/or body mass index (BMI) < 14.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 7, 2026