Cardiotoxicity assessment by gated-single photon computed tomography (SPECT) in patients with previous breast cancer undergoing chemo- and/or radiotherapy

Cardiotoxicity assessment by gated-SPECT in patients with previous breast cancer undergoing chemo- and/or radiotherapy for comparison of coronary reserve

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000584033

Acronym

CFRBC

Enrollment

Registered

2010-07-20

Start date

2010-07-05

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Assessment of coronary flow reserve by non-invasive methodology (myocardial perfusion scintigraphy and cardiac function evaluation) in patients undergoing chemo- and or radio-therapy following breast cancer surgery. Such non invasive procedure could be useful in detecting early microvascular coronary bed damages due to adiuvant interventions

Interventions

Anthracyclines: one cycle once every 21 days for 4-6 cycles; bolus as per imput infusion (comprehensive procedure duration half an hour), 90 mg/m2: radiotherapy on chest 5 day per week for 6 weeks; overall 60 Gy. overall observation over 48 months

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

patients with previous breast cancer undergoing chemo- and or radiotherapy

Exclusion criteria

know coronary artery disease, cardiac heart failure (CHF), hypertrophic myocardiopathy

Outcome results