None listed
Conditions
Brief summary
Studies have shown that adequate maternal docosahexanoic acid (DHA) intake during pregnancy is an important factor for optimal development of the foetus. Fish is a good source of DHA, however, its intake in Australian women is generally low and well below recommendation. This 8-week study aims to determine if a diet higher in fish (providing an average of at least 200mg of DHA/day) obtained from consuming Australian fish 4 times a week can improve health-related bio-makers and outcomes (e.g. erythrocytes membrane n-3 concentrations, lipids, inflammatory markers, depression score) without compromising iron nutriture when compared to a typical Australian diet that is generally low in fish and higher in meat. This study will also predict the blood level of mercury if the higher fish dietary pattern was to be maintained long term.
Interventions
A diet higher in fish. Participants will substitute their usual meat meals with study food provided on four occasions each week. Study food comprises of a variety of Australian fish and fish products (raw and processed) and provides at least 200mg per day of docosahexanoic acid (DHA) on average. Participants will be advised to maintain their usual diet throughout the study period except for the four replacement meals and to avoid foods that are high in omega-3 fatty acids. Duration of interventi
A diet higher in fish. Participants will substitute their usual meat meals with study food provided on four occasions each week. Study food comprises of a variety of Australian fish and fish products (raw and processed) and provides at least 200mg per day of docosahexanoic acid (DHA) on average. Participants will be advised to maintain their usual diet throughout the study period except for the four replacement meals and to avoid foods that are high in omega-3 fatty acids. Duration of intervention is 8 weeks with a 2-week run-in period.
Sponsors
Lynne Cobiac
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy women volunteers 18-50 years of age who are not pregnant and not trying to become pregnant for the duration of the study Body Mass Index [BMI] >=18.5 to <30 kg/m2 and relatively stable in body weight over the last 3 months (less than +/- 5% of body weight change) Provides written informed consent Willing to comply to study procedures
Exclusion criteria
Male; >50 years of age; Currently pregnant or trying to become pregnant, lactating, perimenopausal or postmenopausal; BMI< 18.5 or >=30 kg/m2 or high variation in body weight over the last 3 months (+/- 5% or more of body weight change) or has intention to modify weight status during the study period; Daily consumer of fish oil or other supplements which could interfere with lipid metabolism; Bleeding disorder; Type 1 or type 2 diabetes (fasting blood glucose >=7mmol/L); Cardiovascular disease (e.g. unstable angina, heart failure, hypertension {systolic blood pressure [SBP] >140 mmHg or diastolic blood pressure [DBP] >90 mmHg, average of two readings}); Dyslipidaemia (total cholesterol > 5.5 mmol/L or triglyceride > 2 mmol/L); Chronic inflammatory disease (e.g. rheumatoid arthritis, Crohn’s Disease, ulcerative colitis); Taking any medication or suffering from any condition that is incompatible with the study (e.g. regular users of non-steroidal anti-inflammatory drugs); Seafood allergy; Vegetarian or vegan; Irregular physical activity pattern during study period; Usual diet includes more than one fatty fish meal per week on average; Women working in occupations with regular exposure to mercury
Outcome results
None listed