None listed
Conditions
Brief summary
This study has been designed to investigate how energy intake at a buffet meal will be affected when the meal is presented at different times following a nutrient preload, and and how it is related to antral area, gut hormones and appetite sensations. Volunteers are required to visit the department on 4 occasions approximately 1 week apart. They will be required to ingest either a water or liquid nutrient preload, and 2D Ultrasound scans, blood samples and VAS will be taken at various timepoints depending on the treatment. A buffet meal will be presented 30, 90 or 180 min after the preload, and will be consumed over 30 min until the volunteer is comfortable full.
Interventions
Three 500ml nutrient preloads (Ensure; 2240kJ (2.24MJ)), taken at t = 180 (Study Condition EI180), t = 90 (Study Condition EI90), t = 30 (Study Condition EI30), and one 500ml water preload (control condition). The same nutrient preload will be taken in all study conditions, excluding the water control condition.
Appetite sensation questionnaires in the form of a Visual Analogue Scale (VAS), blood samples, 2D Ultrasound scan to assess antral area.
A buffet meal will be presented 30, 90 or 180 m
Three 500ml nutrient preloads (Ensure; 2240kJ (2.24MJ)), taken at t = 180 (Study Condition EI180), t = 90 (Study Condition EI90), t = 30 (Study Condition EI30), and one 500ml water preload (control condition). The same nutrient preload will be taken in all study conditions, excluding the water control condition. Appetite sensation questionnaires in the form of a Visual Analogue Scale (VAS), blood samples, 2D Ultrasound scan to assess antral area. A buffet meal will be presented 30, 90 or 180 minutes after the nutrient preload ingestion, and 180 minutes after the water preload ingestion, and the participant has 30 minutes to eat until comfortably full. The buffet meal consists of 300ml orange juice, 600ml water, 375ml iced coffee, 4 slices white bread, 4 slices brown bread, 100g deli leg ham, 100g virginian chicken, 4 slices cheese, 100g tomato, 100g cucumber, 100g lettuce, 2 portions mayonnaise, 2 portions margarine, 1 medium apple, 1 medium banana, 200g chocolate custard, 150g fruit salad, and 200g strawberry yoghurt. Each volunteer will recieve one nutrient preload on each of 3 study days, and the water preload on the remaining study day. Each study visit will be separated by approximately one week, and will last approximately 2-4 hours.
Sponsors
Christine Feinle-Bisset
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Non-obese with a Body Mass Index (BMI) of 19-25kg/m2) and obese with a BMI >30kg/m2 and waist circumference > 102cm for males and >97cm for females. Female subjects will be included on the basis that they are using an appropriate contraceptive method (i.e. oral contraceptive pill, diaphragm, Depo-Provera hormonal contraceptive injection, intrauterine device (IUD), Norplant method).
Exclusion criteria
Significant gastrointestinal symptoms, disease or surgery. Current use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal (GI) function, body weight or appetite (e.g. domperidone and cisapride, anticholinergic drugs (e.g. atropine), metclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St John's Wort etc). Significant illness as assessed by the investigator.
Outcome results
None listed