The effects of Posture and Continuous Positive Airway Pressure (CPAP) on lung function in patients recovering from an acute exacerbation of heart failure

In patients who have been admitted with worsening of their heart failure, does continuous positive airway pressure compared to oxygen result in an improvement in lung function?

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000556044

Enrollment

100

Registered

2010-07-09

Start date

2010-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to evaluate the effects of CPAP compared to oxygen on lung function in subjects as they recover from an episode of worsening heart failure. Subjects will be recruited on admission and have serial testing of their lung function early in their admission, just prior to discharge and 30 days following discharge. The effects of posture on lung function will also be evaluated.

Interventions

10 minutes of continuous positive airway pressure at 10cm H2O pressure via nasal or full face mask in the sitting position Followed by 10 minutes of continuous positive airway pressure at 10cm H2O pressure via nasal or full face mask in the supine position

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

Patients admitted to The Alfred with the diagnosis of an exacerbation of cardiac failure Previous diagnosis of heart failure based on echocardiography Stable clinical status: Respiratory Rate<35, oxygen saturation via pulse oximetry (SpO2) > 84% on room air, systolic blood pressure >90mmHg, clinically well perfused and able to talk sentences Co-operative, able to give consent

Exclusion criteria

Pregnancy History of chronic lung disease requiring long term (>4 weeks) treatment Severe renal (requiring dialysis) or neurological disease Recent myocardial infarction (< 6 weeks) Require intravenous inotropes

Outcome results