Efficiency of carbetocin in the prevention of the postpartum haemorrhage :a clinical double-blinded randomized study .

Comparison of the effectiveness of carbetocin vs oxytocin in managing the third stage of labor in a group of women with risk factors for postpartum hemorrhage.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000550000

Enrollment

140

Registered

2010-07-08

Start date

2010-07-15

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Postpartum haemorrhage (PPH) is a major cause of morbidity and mortality in the world. The present study aims to compare the effectiveness of carbetocin and oxytocin in the prevention of bleeding that occurs within 24 hours after delivery, in a group of pregnant women with risk factors for PPH.

Interventions

carbetocin ampule x 100 mcg diluted in 10 cc of saline administered as a single intravenous bolus dose in the management of the third phase of labor.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Pregnancy over 34 weeks. 2. Hold at history a risk factor for postpartum haemorrhague as nulliparous, multiple pregnancy, hypertensive disease, induction of labor, fetal macrosomia fetus, more than 35 years, obesity, second period of prolonged labor, precipitate labor, chorioamnionitis and prolonged third period of labor.

Exclusion criteria

1. Mental retardation. 2. Coagulation disorder. 3. Renal failure. 4. Liver failure. 5. Heart failure. 6. Heart rhythm disorders. 7. Central placenta previa total. 8. Indication of caesarean.

Outcome results