None listed
Conditions
Brief summary
Children/Tamariki with lung problems often need help with their breathing. There are several ways of doing this, but the problem with the current methods is that they involve uncomfortable straps on the face which children/Tamariki do not like. We have a new and better-tolerated method of delivering oxygen, which helps babies and children/ Tamariki breathe more easily. It uses nasal “prongs” very similar to that used for standard oxygen delivery but modified to be able to use a faster flow of oxygen. It has been used successfully in babies and children/Tamariki worldwide. We would like to better understand how this treatment works and how best to adjust it for individual patients. We will give different flow rates of oxygen and measure how much easier it is for the child/Tamariki to breathe. To do this we use a modified feeding tube, a very fine tube in the nose to measure the pressure there, loosely apply stretchy bands to the chest and abdomen to measure breathing, and we stick a dot to the skin to measure gas levels. These have minimal risk. This work will help us determine how much oxygen is best for each child/Tamariki.
Interventions
Measurement of pharyngeal pressure and work of breathing of children receiving nasal high flow oxygen over a period of one to two hours.
For those children on low flow oxygen, measurements will be made on low flow. High flow nasal cannulae will be applied, and flow applied at 1L/kg/min, then 2L/kg/min, then 3L/kg/min, then 4L/kg/min. Measurements will be taken after 10 minutes on each flow rate. Before increasing to a new flow rate, flow will be decreased to 1L/kg/min for 2 minutes. The flow w
Measurement of pharyngeal pressure and work of breathing of children receiving nasal high flow oxygen over a period of one to two hours. For those children on low flow oxygen, measurements will be made on low flow. High flow nasal cannulae will be applied, and flow applied at 1L/kg/min, then 2L/kg/min, then 3L/kg/min, then 4L/kg/min. Measurements will be taken after 10 minutes on each flow rate. Before increasing to a new flow rate, flow will be decreased to 1L/kg/min for 2 minutes. The flow will be delivered to a maximum of 60L/minute. For children already receiving nasal high flow oxygen, the measurements will be made on high flow oxygen, then on low flow oxygen at 2L/minute if deemed safe by the treating team. Children on continuous positive airways pressure (CPAP) will have nasal high flow oxygen prongs applied, then will have the measurements made as above.
Sponsors
Dr Jan Kelly
Study design
Allocation
Non-randomised trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to 16 Years
Healthy volunteers
No
Inclusion criteria
Respiratory distress (either primary or secondary) who are receiving nasal high flow oxygen or continuous positive airways pressure; or require greater than or equal to 2L/min of oxygen via nasal prongs, and have at least moderate work of breathing as determined by the treating team
Exclusion criteria
Children who require intubation and invasive ventilation. Children with a contraindication to nasal canulae and non invasive ventilation
Outcome results
None listed