None listed
Conditions
Brief summary
People with kidney failure often develop a condition called ‘uraemic neuropathy’, where the function of the nerves in the hands and feet is impaired. These changes cause weakness, numbness and tingling. Our studies have shown that high levels of potassium in the bloodstream may cause uraemic neuropathy. The purpose of this study is to investigate whether reducing the amount of potassium in a patient’s diet may help prevent neuropathy.
Interventions
Strict dietary potassium (K+) restriction with Dietitian support - including an initial consultation, 2 week follow-up consultation with fortnightly phone calls for the first 3 months after which the patient will receive a phone call one month and a face to face consultation the next for the remaining months of the total 24 month trial. If serum K+ levels exceed the target of 3.5-4.5mmol/L for more than 2 months dietary advice will be supplemented by an oral solution of resonium (15-30mg per ni
Strict dietary potassium (K+) restriction with Dietitian support - including an initial consultation, 2 week follow-up consultation with fortnightly phone calls for the first 3 months after which the patient will receive a phone call one month and a face to face consultation the next for the remaining months of the total 24 month trial. If serum K+ levels exceed the target of 3.5-4.5mmol/L for more than 2 months dietary advice will be supplemented by an oral solution of resonium (15-30mg per night as prescribed by the treating physician based on the clinical variables) until K+ falls back within normal range.
Sponsors
Dr Arun Krishnan
Study design
Allocation
Randomised controlled trial
Intervention model
Factorial
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
History of Chronic Kidney Disease (stage 3 or 4), as defined by the estimated glomerular filtration rate. Monthly attendance for clinical care at Kidney Care Centre, Prince of Wales Hospital. Able to provide informed consent
Exclusion criteria
Current or past history of dialysis therapy or previous renal transplantation. Cognitively impaired Unable to speak and/or understand English Pregnant
Outcome results
None listed