None listed
Conditions
Brief summary
This study is to investigate the effect of MM on cognitive functions, such as working memory, recognition, attention, etc. The study predicts that MM treatment is associated with additional impaired cognitive function.
Interventions
A parallel group cross-sectional design will be used to compare the cognitive functioning of three independent groups.
1 Opiate-dependent subjects enrolled in MM treatment
2 Currently opiate-dependent subjects not enrolled in MM treatment
3 Healthy controls without history of substance abuse.
Psychometric testing will be performed once with all participants and participants will have an Electroencephalography(EEG) on a single occasion to assess neurophysiological function. A computerized psych
A parallel group cross-sectional design will be used to compare the cognitive functioning of three independent groups. 1 Opiate-dependent subjects enrolled in MM treatment 2 Currently opiate-dependent subjects not enrolled in MM treatment 3 Healthy controls without history of substance abuse. Psychometric testing will be performed once with all participants and participants will have an Electroencephalography(EEG) on a single occasion to assess neurophysiological function. A computerized psychometric test and electroencephalographic (EEG) assessment takes about 2.5 hours total. Methadone has been used as a pharmacotherapy for opioid dependence since the mid-1960s. It is an opioid drug, taken orally and rapidly absorbed. It can active over 24 to 36 hours and effectively minimise the euphoric effect of opiate and aversive effects of opiate withdrawal.
Sponsors
University of Auckland
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria for the MM group include: 1. aged between18 and 45 inclusive 2. with a history of heroin/ other opiate dependence 3. being stabilised in their current methadone dose for at least 2 weeks 4. basic English literacy skills 5. able to provide written consent Inclusion criteria for the current opiate-dependent users include: 1. aged between18 and 45 inclusive 2. met the Diagnostic and Statistical Manual of Mental Disorders - 4th Edition (DSM-IV) criteria for heroin/other opiate dependence in the 1 year period prior to the study 3. basic English literacy skills 4. able to provide written consent Inclusion criteria for health controls include: 1. aged between18 and 45 inclusive 2. no history of substance abuse 3. basic English literacy skills 4. able to provide written consent
Exclusion criteria
Exclusionary criteria for all participants include current or lifetime history of psychotic disorder, depression, cardiac disease, endocrine disorder, head trauma, or neurological disease.
Outcome results
None listed