Comparison of Inflammation, Oxidative Stress, and Respiratory Outcomes Between Conventional and Protective One Lung Ventilation in Patients Undergoing Lung Resection Surgery

Comparison of Inflammation, Oxidative Stress, and Respiratory Outcomes Between Conventional and Protective One Lung Ventilation in Patients Undergoing Lung Resection Surgery for Lung Cancer

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000477022

Enrollment

Registered

2010-06-10

Start date

2009-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study compared inflammatory and oxidative stress, and respiratory outcomes between conventional and protective OLV in patients with normal lung function undergoing video-assisted thoracoscopic (VATS) lobectomy due to lung cancer. Fifty ASA 1-2 patients undergoing elective VATS lobectomy were randomly assigned into conventional (CV: tidal volume 10 ml/kg, FiO2 1.0, zero positive end-expiratory pressure under volume-controlled ventilation) or protective (PV: tidal volume 6 ml/kg, FiO2 0.5, positive end-expiratory pressure 5 cmH2O under pressure-controlled ventilation) OLV group. Respiratory parameters, arterial blood gases, blood malondialdehyde (MDA) and interleukin 6 (IL 6) were analyzed at baseline, 15 min and 60 min after OLV (OLV 15 and OLV 60, respectively), and 15 min after the restoration of two lung ventilation (TLV 15). Postoperative chest radiography (CXR) and respiratory outcomes were also evaluated.

Interventions

Protective One Lung Ventilation (tidal volume 6 ml/kg, 5cmH2O positive end-expiratory pressure, inspiratory oxygen partial pressure:FiO2 0.5) / continuously applied during lobectomy (approximately 60-90 minutes).

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

American Society of Anesthesiologist (ASA) physical status 1-2 and scheduled for an elective video-assisted thoracoscopic (VATS) lobectomy due to lung cancer

Exclusion criteria

patient’s refusal to take part in the study, coexisting chronic obstructive lung disease with forced expiratory volume in 1 s of less than 80% of predicted and/or forced expiratory volume in 1 s over forced vital capacity ratio of less than 0.7, chronic renal failure, altered liver function, preoperative corticosteroid treatment during one month before operation, elevated temperature or leukocyte count, or any new pulmonary infiltration on the chest radiography (CXR).

Outcome results