None listed
Conditions
Brief summary
There is good evidence of a true synergy between midazolam and propofol induction and data suggests that pre-dosing with propofol also reduces induction requirements. However, there has been no measure of the actual cardiac output changes in any human studies apart from that of Adachi et al. We plan to explore the relationship between cardiac output and induction doses of propofol in more detail and, in particular, to explore the effect of co-induction agents on cardiac output and to further evaluate cardiac output changes around induction of anaesthesia.
Interventions
Administration of a small dose of midazolam (0.03mg/kg), propofol (0.4mg/kg), fentanyl (1.5mcg/kg) or placebo by intravenous bolus, 3 minutes prior to induction of anaesthesia by propofol, infused at a rate of 3ml/kg/hr until loss of consciousness as confirmed by syringe drop.
Sponsors
Christchurch Anaesthesia Education Trust
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Surgery requiring insertion of arterial line, American Society of Anesthetist (ASA) rating 1,2 or 3
Exclusion criteria
Contra-indication to propofol. Requirement for specific co-induction drug, other than study drug.
Outcome results
None listed