None listed
Conditions
Brief summary
Fibrotic tissue may cause myocardial dysfunction and failure. So it’s important to establish a non invasive method to assess myocardial fibrosis. Cardiac MR relaxometry can quantify myocardial fibrosis using tagging, T2 star quantification, T1 mapping, first pass perfusion and delayed enhancement techniques. These results will correlate with the echocardiography methodology and myocardial biopsy findings. the aims of this study to determine a MRI relaxometry of normal myocardium and any Alteration of relaxation times for early fibrosis in hypertensive disease. also, To detect possible fibrosis of remote myocardium in patients with prior infarction by analysis of delayed enhancement images after injection of MRI contrast agent. The hypothesis of this study is that Magnetic Resonance relaxometry can assess and measure early diffuse fibrosis in hypertensive heart disease. the expected benefits from this study is Understanding the Tost effective clinical treatments will lead to improved health outcomes at lower cost. also, Early intervention is known to reduce the cost burden to the community and healthcare delivery system. in addition, Validation of non invasive methods of measuring early fibrotic changes in myocardium is essential to direct the clinical decision making
Interventions
Fibrosis tissue accumulation is an integral feature of the adverse structural remodelling of cardiac tissue seen with hypertensive heart disease. Given the importance of fibrosis tissue in leading to myocardial dysfunction and failure.
The volunteers and patients will undergo an Magnetic resonance imaging (MRI) for one time only.
MRI is a painless non-invasive technique that involves lying in a scanner to create image based on magnetic signal of the protons inside the human body.
Cardiac MRI r
Fibrosis tissue accumulation is an integral feature of the adverse structural remodelling of cardiac tissue seen with hypertensive heart disease. Given the importance of fibrosis tissue in leading to myocardial dysfunction and failure. The volunteers and patients will undergo an Magnetic resonance imaging (MRI) for one time only. MRI is a painless non-invasive technique that involves lying in a scanner to create image based on magnetic signal of the protons inside the human body. Cardiac MRI relaxometry has variuos techniques, which includes standard magnetic resonance imaging (MRI) sequences including tagging, Modified Look-Locker Inversion recovery imaging (MOLLI), to early detection of myocardial fibrosis. These technique have ability to assess abnormal structure and function of the heart. The scanning takes about 20 to 25 minutes for normal volunteers and the patients takes about 45 Minutes due to repeat of MRI technique after 8 minutes delay injection of MRI contrast agent. The patients will be injected by MRI contrast agent (Gadolinium) to assess any possibility of scarring tissue in the myocardium. Then, the MRI result will correlate with echocardiography and histopathology findings.
Sponsors
the University of Queensland
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
The patient cohort (OVER 40 YEARS) will comprise apparently healthy patients and patients with high blood pressure with normal and abnormal cardiac function recruited from the hospital clinic and the community
Exclusion criteria
1)- Women who are pregnant and the human fetus. 2)- Children and/or young people (i.e. <40 years). 3)- People with an intellectual or mental impairment. 4)- People highly dependent on medical care. 5)- People in existing dependent or unequal relationships with any member of the research team, the researcher(s), and/or the person undertaking the recruitment /consent process. 6)- A history of drug abuse that would interfere with the ability to comply with the study protocol.
Outcome results
None listed