The Effect of Anaesthetic Preconditioning on Lung Injury during One Lung Ventilation undergoing Transthoracic Esophagectomy

Comparison of Plasma interleukin-6 between sevoflurane preconditioning and non-conditioning groups in patients undergoing transthoracic esophagectomy

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000410055

Enrollment

Registered

2010-05-21

Start date

2009-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Pulmonary complication after one lung ventilation (OLV) is one of serious complications after transthoracic esophagectomy (TTE). The authors designed this study to investigate that the preconditioning of volatile anesthetics could decrease the production of pro-inflammatory cytokines or oxygen free radicals and decrease the development of pulmonary complications in the patients undergoing TTE. Forty-five adults undergoing TTE with OLV will be randomly assigned to receive sevoflurane anaesthesia (group S), total intravenous anaesthesia (TIVA) using propofol with remifentanil (group T), or sevoflurane preconditioning group (group T/S).The concentrations of plasma interleukin-6 (IL-6) and plasma malondialdehyde (MDA) will be assessed before and after OLV as the primary endpoint. The clinical outcome between group S and group T will be compared as the secondary endpoint.

Interventions

In the group T and group T/S, propofol and remifentanil will be administered to end organ concentrations of 5.0 microg ml-1 and 4.0 ng ml-1, respectively, using a target-controlled infusion (TCI) pump (Orchestra, Fresenius Vial, France) from induction of anesthesia. In the group T/S, 30 minutes before induction of one lung ventilation, total intravenous anesthesia(TIVA) will be stopped and replaced by 2 vol% sevoflurane. Namely, group T/S will receive propofol and remifentanil, followed by 30

Study design

Allocation

Randomised controlled trial

Intervention model

Factorial

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

American Society of Anaesthesiologists physical status I-III undergoing transthoracic esophagectomy

Exclusion criteria

high body temperature (over 37degrees celsius), increased levels of C-reactive protein (CRP) and white blood cell (WBC), administration nonsteroidal anti-inflammatory agent (NSAIDs) or corticosteroid within 3months, vital capacity (VC) or peak expiratoty volume at 1 minute (FEV1) less than 50% of expected.

Outcome results