Nutritional status in Parkinson’s disease pre- and post-deep brain stimulation surgery

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12610000369022

Enrollment

Registered

2010-05-10

Start date

2010-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

While it is known that patients with Parkinson’s disease (PD) lose more weight and have a higher risk of decreased bone mineral density and increased inflammation when compared with age-matched controls, and deep brain stimuation of the subthalamic nucleus (STN-DBS surgery) in PD is followed by weight gain, there has been limited research that has investigated specific factors that impact upon nutritional status in PD. There has also been limited research in regards to the measurement of nutritional status in Parkinson’s disease. The overall aim of this project is to determine the influence of motor and non-motor symptoms and inflammation on nutritional status in people with Parkinson’s disease and how deep-brain stimulation modifies the severity of symptoms and inflammation and therefore their impact on nutritional status. The specific aims of the proposed project are to: *Identify potential factors influencing nutritional status changes in Parkinson’s disease. *Evaluate the effectiveness of available subjective and objective tools in the assessment of nutritional status in Parkinson’s disease. *Provide evidence to inform effective nutritional interventions aiming to address the decline in nutritional status associated with Parkinson’s disease.

Interventions

Exposure: Deep brain stimulation surgery of the sub-thalamic nucleus: This involves the stereotactic implantation of stimulating electrodes in the sub-thalamic nucleus of the brain. Implanted stimulating electrodes are routed subcutaneously and connected to a permanently implanted stimulating device usually fixed within the pectoral or rectus abdominus fascia. The entire process takes 5 to 7 hours; the surgery generally takes 3 to 4 hours.

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

Deep brain stimulation (DBS) Parkinson's disease (PD) group (DBS-PD): diagnosis of idiopathic Parkinson's disease, scheduled for deep brain stimulation of the sub-thalamic nucleus. Parkinson's disease control group: diagnosis of idiopathic Parkinson's disease, not scheduled for deep brain stimulation; age, gender, disease duration matched to DBS-PD participants Elderly control group: no diagnosis of idiopathic Parkinson's disese; age and gender matched to DBS-PD participants

Exclusion criteria

Previous surgery for Parkinson's disease; unable to provide informed consent; presence of a co-morbidity (unstable cardiovascular disease, heart failure, liver failure, chronic kidney disease requiring dialysis, cancer, human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), chronic obstructive pulmonary disease) or acute illness which could influence the presence of nutrition impact symptoms and/or nutritional status

Outcome results