None listed
Conditions
Brief summary
Modern anaesthesia incorporates the use of short-acting opioids such as remifentanil. Lately, there has been emerging evidence in the literature that some opioids might influence postoperative sleep quality for up to many months. We aim to compare sleep quality after exposure to 2 opioids regularly used in the clinical routine at Royal Perth Hospital.
Interventions
Patients receive remifentanil-based anaesthesia during their elective operation. This is a one off treatment. Remifentanil is continuously infused intravenously at a rate of 0.15 - 0.3 mcg/kg/min. The infusion starts on induction of anaesthesia and finishes after the surgical procedure before emergence. Approximate duration of anaesthesia is between 45 and 120 minutes.
Sponsors
Manuel Wenk
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Surgery under general anaesthesia Perioperative Anaesthesia Risk Status according to American Association of Anesthesiology (ASA) I-III Estimated anaesthesia time > 60 minutes
Exclusion criteria
Age< 18, Head Injury, Cardiac Surgery, Alcohol addiction, Other drug addictions, ASA > III, incapacity to consent, medication with drugs known to potentially interact with sleep quality (e.g. benzodiazepines, ketamine, beta-receptor-blockers), previous and continueing use of opioids.
Outcome results
None listed