Effect of combined fish oil and coenzyme Q10 supplementation on liver fat composition, liver fat content and cardiovascular risk factors in overweight men

Effect of combined fish oil and coenzyme Q10 versus placebo on hepatic triglyceride concentration in overweight men

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000351011

Enrollment

Registered

2010-05-03

Start date

2011-06-07

Completion date

2014-04-07

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To investigate whether supplementation with combined fish oil/CoQ10 alters hepatic triglyceride concentration, composition and cardiovascular risk factors in overweight men.

Interventions

4 capsules (4g) per day for 12 weeks to be consumed orally of docosahexaenoic fatty acid supplement (total dose of 1g of eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA] combined and 200mg of coenzyme Q10 [CoQ10]/day)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

Overweight men: body mass index (BMI) greater than 25 but less than 30 with a waist circumference greater than or equal to 94cm.

Exclusion criteria

history of heart, lung or kidney disease; smoking and excess alcohol consumption; known allergy to fish or other seafood; a haemorrhagic disorder, or receiving anticoagulants and/or other drugs affecting coagulation; hepatic impairment (i.e., severe liver enzyme elevation); supplements or medications known to affect outcome measures.

Outcome results