None listed
Conditions
Brief summary
There is a growing body of research indicating that vitamin D blood concentrations can impact on brain functioning. In particular, there is robust evidence in animal models showing that vitamin D deficiency during development impairs brain functioning in adulthood. However, no studies have examined whether enhancing vitamin D blood concentrations by vitamin D supplementation during adulthood can improve brain functioning. This study will assess whether increasing vitamin D blood concentrations via vitamin D supplementation in healthy adults improves various aspects of brain functioning such as attention, response inhibition, and general mood and emotions. We anticipate that this study will provide us with important information about the effects of enhancing vitamin D blood concentrations on brain function in healthy adults.
Interventions
Vitamin D (Cholecalciferol 5000 IU) capsules, 1 capsule daily for 6 weeks
Sponsors
The University of Queensland
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
aged 18 years or over provision of consent to participate.
Exclusion criteria
1) current use of vitamin D or calcium supplements; 2) having past adverse reactions to vitamin supplements; 3) current or recent use of psychotropic medications or medications which may influence vitamin D absorption (e.g. cholestyramine, orlistat) 4) current or past diagnosis of psychotic disorders; 5) serious neurologic illnesses including stroke, brain tumours, head trauma, multiple sclerosis, epilepsy, movement disorders or migraine in treatment; 6) drug dependency on alcohol or illicit substances; 6) intellectual disability 7) pregnancy or current breast feeding, or potential to become pregnant during the trial; 8) history of severe renal impairment, 9) recent or current use of immunosuppressive therapy.
Outcome results
None listed