None listed
Conditions
Brief summary
Current approaches to counter dental caries are mainly limited to fluoride treatments which include water fluoridation, fluoridated toothpastes, and professionally applied topical fluoride preparations. The effectiveness of fluoride is limited as almost half the NZ population has an unfluoridated water supply, and toothpaste use is infrequent for many people. New approaches and interventions are needed. The overall aim of our research is to counter caries development by depositing a tooth-like mineral into dental plaque by using a plaque-mineralising toothpaste containing the tooth minerals, calcium and phosphate. The aim is to protect the tooth mineral from acid dissolution, enhance the effectiveness of remineralization induced by fluoride (which will also be supplied in the toothpaste), and modify the plaque microbial composition. This trial is designed to evaluate the efficacy of the plaque mineralising toothpaste by determining the levels of mineral deposited in dental plaque in vivo after its use over a four week period. This study is based on laboratory-based findings in our previous studies.
Interventions
Plaque mineralising toothpaste to be used twice daily (morning and evening) for 4 weeks
Sponsors
University of Otago
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
Radiation Therapy and Medical Students at the University of Otago Wellington
Exclusion criteria
Requirement to treat for periodontal disease or other immediate dental treatment needed. History of rheumatic heart disease/fever
Outcome results
None listed