Retinal Artery Study in participants with obstructive sleep apnoea treated with continuous positive airway pressure

A pilot, randomised controlled trial of retinal artery flicker induced vasodilatation to detect change in endothelial function in participants with obstructive sleep apnoea treated with continuous postitive airway pressure for 6 weeks.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610000311055

Enrollment

Registered

2010-04-19

Start date

2010-04-15

Completion date

2010-12-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Evidence has accumulated that changes to the tiny blood vessels at the back of the eye (retinal arteries) are linked to heart disease. It is possible to use a simple eye examination to view these tiny retinal blood vessels and get an idea about their condition. This kind of examination is simple to perform and is not invasive. Because there are similarities to blood vessels throughout the body, an eye examination could be used to provide important information about blood vessel condition in general and whether certain treatments can result in improved blood vessel function. This study will examine the retinal arteries of a group of patients with Obstructive Sleep Apnoea and risk factors for or actual heart disease. It will also look for evidence that the function of the retinal arteries improves with Continuous Positive Airway Pressure (CPAP) treatment

Interventions

6 weeks Continuous Positive Airway Pressure (CPAP) individually titrated and fitted for use during sleep.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Moderate to severe Obstructive Sleep Apnoea(OSA) - Apnoea Hypopnoea Index greater than or equal to 30, with associated hypoxaemia – Oxygen saturation(Sa O2) <90% for a minimumm of 6% of total sleep time. Actual coronary artery disease or two or more of the following cardiovascular risk factors – hypertension, dyslipidaemia, diabetes, smoking, positive family history.

Exclusion criteria

Commercial driver or patients listed for urgent CPAP implementation. Glaucoma

Outcome results