None listed
Conditions
Brief summary
Pharmacological models have a variety of applications, including automated drug infusion pumps and human patient simulators. These applications often extrapolate models beyond the datasets in which they were developed, and the uses for which they were designed. As such, models require validation in new datasets to ensure adequate performance. Collection of drug administration and effect data can be used to validate drug dose – effect models. We will prospectively collect data from surgical cases at Auckland City Hospital. This will allow construction of an observational dataset from which current pharmacological models can be validated in our patient population.
Interventions
This is a prospective, observational study. We will collect physiological and anaesthetic data prospectively for anaesthetics completed at Auckland City Hospital in the next two years. Electronic anaesthetic records will be collected and physiological data, patient demographics, and any other routinely collected information will be extracted. Data from all physiological monitoring will be directly downloaded during the procedure. Please note: this will not alter standard patient care. Use of all
This is a prospective, observational study. We will collect physiological and anaesthetic data prospectively for anaesthetics completed at Auckland City Hospital in the next two years. Electronic anaesthetic records will be collected and physiological data, patient demographics, and any other routinely collected information will be extracted. Data from all physiological monitoring will be directly downloaded during the procedure. Please note: this will not alter standard patient care. Use of all standard and additional monitoring will remain at the discretion of the anaesthetist. In addition, software designed to accurately read and log drug infusion rates from automated Total Intravenous Anaesthesia (TIVA) pumps will collect drug bolus and infusion rate data directly.
Sponsors
Department of Anaesthesiology, University of Auckland
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients receiving general anaesthesia from six demographic groups will be studied: * Healthy Adults: 18 - 65 years; body mass index 18.5 - 25 (as defined by the World Health Organisation) * Cardiac bypass patients * Elderly, defined as age > 70 years * Overweight, body mass index > 30 * Those who receive total intravenous anaesthesia * American Society of Anesthesiologists (ASA) grade 3-4 patients undergoing emergency surgery
Exclusion criteria
Patients with neurological dysfunction, head trauma, opioid dependence and renal or hepatic co-morbidities will not be studied
Outcome results
None listed